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Davis, Jim (Physics)

Jeffrey, Kenneth R. (Physics)

Ladizhansky, Vladimir (Protein NMR Research Group, Physics)

Penner, Glenn (Chemistry)

Sameer Al-Abdul-Wahid (NMR Facility)



CanadianGraduate student NMR positions at Guelph (April 2/15)

We are seeking MSc and PhD students to work in the protein NMR group at the University of Guelph. Our group is interested in the development of solid-state NMR methods for the characterization of membrane protein structure, dynamics and interactions. The research will be conducted at the University of Guelph NMR Centre, which is equipped with an array of solid-state NMR spectrometers operating at field strengths from 500 MHz to 800 MHz, and with a 600 MHz/395 GHz Dynamic Nuclear Polarization (DNP) NMR spectrometer (http://nmr.uoguelph.ca/). The specific projects will deal with studying protein-protein interactions and dynamics at the membrane-solvent interface, and with the development of DNP methodologies.

The candidates must have a degree in chemistry, physics or biochemistry. Applications are accepted to both the Department of Physics http://www.physics.uoguelph.ca
or Biophysics Interdepartmental Group https://www.uoguelph.ca/biophysics/welcome-biophysics

For more information contact

Vlad Ladizhansky
http://www.physics.uoguelph.ca/~vladimir/

------
Dr. Vladimir Ladizhansky
Associate Professor
Department of Physics
University of Guelph,
50 Stone Road E, Guelph,
Ontario, Canada N1G 2W1
phone: 519-824-4120 Ext 53989
departmental fax: 519-836-9967
email: vladizha "at" uoguelph.ca

NSERC 2014 Competition Results (June 27/14) [NSERC  ]

Discovery Grants

Blaine Chronik (Western) Magnetic Resonance Systems Development

Kalle Gehring (McGill) Protein folding in the endoplasmic reticulum

Paul Hazendonk (Lethbridge) Solid-State NMR of Complex Hybrid Organic-Inorganic Materials

Vladimir Ladizhansky (Guelph) Interactions of membrane proteins with lipids, water, and other proteins in biological membranes

William MacFarlane (UBC) Development and Application of Depth-Resolved beta-Detected Nuclear Magnetic Resonance to electronic, ionic and molecular phenomena in the Solid State

Giuseppe Melacini (McMaster) Solution NMR Studies of Interactions of Ligands With Plasma Proteins

Anthony Mittermaier (McGill) Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions

Geoffrey Ozin (Toronto) Silicon Nanochemistry

Linda Reven (McGill) Solid-State NMR of Polymer and Liquid Crystalline Nanocomposites

Andre Simpson (Toronto Scarborough) Development of flow-based and magic angle spinning in-vivo NMR to understand environmental stress

Jenifer Thewalt (Simon Fraser) Domains in Biologically Relevant Lipid Membranes

David Wishart (Alberta) Development of Improved Methods to Rapidly Characterize Protein Structure, Function and Dynamics

Julian Zhu (Université de Montréal) Versatile Polymeric Biomaterials

Discovery Accelerator Supplement
$120,000 over three years


Giuseppe Melacini (McMaster) Solution NMR Studies of Interactions of Ligands With Plasma Proteins

Research Tools and Instruments (RTI)


Derek Gates (UBC) Upgrade to UBC-Chemistry Departmental NMR Facility

CanadianGraduate student position, the University of Guelph, Guelph, Ontario (April 29/14)

We are seeking highly motivated PhD students to work in the protein NMR group at the University of Guelph. Our group is broadly interested in membrane protein structure. Our main research tool is magic angle spinning solid state NMR, but we also used other complementary biochemical, biophysical and computational methods. The research will be conducted at the University of Guelph NMR Centre, which is equipped with an array of solid-state NMR spectrometers at field strengths from 500 MHz to 800 MHz, and with a recently installed Dynamic Nuclear Polarization spectrometer. This gives us the unique ability to probe atomic level details of molecular structure, dynamics, and interactions. The specific project will deal with protein-lipid and protein-water interactions, with emphasis on the methodological aspect.

For examples of our work, see our recent publications: http://www.nature.com/nmeth/journal/v10/n10/full/nmeth.2635.html
http://pubs.acs.org/doi/abs/10.1021/ja411633w

The candidates must have a degree in chemistry, physics or biochemistry.

Applications are accepted to both, the Department of Physics
http://www.physics.uoguelph.ca
or Biophysics Interdepartmental Group
https://www.uoguelph.ca/biophysics/welcome-biophysics

For more information contact

Dr. Vladimir Ladizhansky
Associate Professor and Canada Research Chair II,
Department of Physics
University of Guelph,
50 Stone Road E, Guelph,
Ontario, Canada
N1G 2W1
phone: 519-824-4120 Ext 53989
departmental fax: 519-836-9967
email: [vladizha "at" uoguelph.ca]
http://www.physics.uoguelph.ca/~vladimir/


NMR paper in Nature Methods (Sept 9/13)

S. Wang, R.A. Munro, L. Shi, I. Kawamura, T. Okitsu, A. Wada, S.-Y. Kim, K.-H. Jung, L.S. Brown and V. Ladizhansky, "Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein," Nature Methods (2013) online.
http://dx.doi.org/10.1038/nmeth.2635

"Research May Lead to New Drugs for Heart Disease, Other Ailments" September 09, 2013 - News Release, University of Guelph http://www.uoguelph.ca/news/2013/09/research_may_le.html

Thesis Defenses

Rebecca Jamieson (University of Guelph) June 2013

Supervisors: Prof. Glenn Penner

Ph.D. Chemistry: "A Solid-state NMR Study of Tin and Phosphorus Containing Compounds"

External Examiner: Prof. Gillian Goward (McMaster)


"Canadian NMR Research" News Bulletin (May 14/13)Spring 2013

Colleagues, the Spring 2013 issue of the "Canadian NMR Research" news bulletin is ready for your attention, our traditional mix of news and research updates. In this issue: DNP-NMR at Guelph, 850 MHz at McMaster, and the first MOOT XXVI announcement. You are welcome to share this bulletin with your colleagues and students.



Recognition: 54th ENC Student Travel Awards (May 1/13)

Following the long tradition, ENC has awarded 2013 Student Travel Stipends to support students attending the 54th ENC Conference held April 14-19, 2013 in Asilomar, California. The stipends were provided by the ENC, the Suraj P. Manrao Science Foundation, and by the generous contributions of sponsors. Among awardees there were several Canadian recipients, including

Jasmine Viger-Gravel (University of Ottawa)
Daryl Good (University of Guelph)
Leayen Lam (University of Toronto)
Alan Manning (University of British Columbia)
Danielle Smiley (McMaster University)
Stanislav Veinberg (University of Windsor)

Congratulations to all the winners!

The final 54th ENC program is now available online
http://www.enc-conference.org

Graduate student positions, University of Guelph (April 25/12)

Graduate student positions are available in the solid state NMR group at the University of Guelph to work on the membrane protein structure determination problems. The University of Guelph NMR Centre is well equipped with an array of solid-state NMR (SSNMR) instruments operating at field strengths of 500, 600 and 800 MHz. Our facility will soon include the first in Canada Dynamic Nuclear Polarization (DNP) enhanced 600 MHz SSNMR spectrometer. We study various large membrane proteins of both bacterial and human origin. Our aim is achieve comprehensive understanding at atomic level of protein structure and functional dynamics. The research carried out in the group is highly interdisciplinary. In addition to multi-dimensional solid-state NMR, we use computational and biophysical methods, and chemical and molecular biology approaches to synthesis and purification of isotopically labeled proteins.
For more information contact Vlad Ladizhansky directly (vladizha "at" uoguelph.ca or ladizha "at" gmail.com)

Dr. Vladimir Ladizhansky
Associate Professor and Canada Research Chair II,
Department of Physics
University of Guelph,
50 Stone Road E, Guelph,
Ontario, Canada N1G 2W1
phone: 519-824-4120 Ext 53989
departmental fax: 519-836-9967
email: vladizha "at" uoguelph.ca
http://www.physics.uoguelph.ca/~vladimir/


Recognition: 53rd ENC Student Travel Awards (April 6/12)

ENC has announced winners of 2012 Student Travel Stipends attending the 53rd ENC, April 15-20, 2012, Miami, Florida. The stipends are funded by the ENC, the Suraj P. Manrao Science Foundation, and the generous contributions of companies. Among awardees there are several Canadian recipients, including

Andrée Gravel (Université du Québec à Montréal)
Emily Ritz (University of Guelph)
Siqi Zhu (McGill University)
Bryan Lucier (University of Windsor)
Hussain Masoom (University of Toronto)
Erick Meneses Ramirez (McGill University)

Congratulations to all the winners!

The finalized 53rd ENC program is now available online
http://www.enc-conference.org



University of Guelph (Dec 7/11)

The University of Guelph is committed to equity in its policies, practices, and programs, supports diversity in its teaching, learning and work environments, and ensures that applications for members of underrepresented groups are seriously considered under its employment equity policy. All qualified individuals who would contribute to the further diversification of our University community are encouraged to apply.

Office, Clerical and Technical
Position covered by the Collective Agreement with USW Local 4120

Nuclear Magnetic Resonance Technician

Dean's Office, College of Physical and Engineering Science

Hiring #:2011-0304

http://www.uoguelph.ca/hr/job-posting-2011-0304

For application instructions, please visit

http://www.uoguelph.ca/hr/careers-guelph/how-apply

The University of Guelph Nuclear Magnetic Resonance (NMR) Centre is equipped with seven Bruker NMR spectrometers, and provides analytical research services, and technical and scientific advice, to both academic and industrial communities. The NMR Technician will assist in the operation and maintenance of the Centre's equipment and associated computer network. Specific duties will include: running samples on both solid and solution state NMR spectrometers; solving complex problems with equipment; maintaining GLP system for industrial samples as required; receiving and handling customer complaints; coordinating instrumental access by users; training non specialized users, such as graduate students and faculty, providing individual training as necessary; monitoring authorized users and recommending retraining or additional training as necessary; maintaining super-conducting magnets; running periodic checks on the NMR spectrometers; performing preliminary diagnosis of electronic malfunctions and minor repairs and other associated duties.

Requirements of the position: a Master's Degree in Chemistry, Physics or Biochemistry combined with 2 years related NMR experience, or an equivalent combination of education and experience. Additional requirements include: a background in NMR spectroscopy; strong customer service skills; scheduling and running training sessions; computer skills; strong organizational abilities; experience with analysing data and excellent oral and written communication skills.

Position Number: 256-003
Classification: USW, Local 4120 Band 7*
Salary Range:
$25.93 Minimum
$35.06 Job Rate (level 7)
$36.67 Maximum

*Tentative evaluation; subject to committee review.

Posting Date: 2011 12 07
Closing Date: 2011 12 14


Stable Isotopes for Structural Biomolecular NMR Stable Isotopes for Structural Biomolecular NMR (July 22/11)

Cambridge Isotope Laboratories (CIL) made available a series of application notes on the use of stable isotopes in Biomolecular NMR. These application notes were written by some of the world's leading researches in the field, including several Canadian scientists.

Lewis Kay (University of Toronto) "Alanine Probes of Supra-Molecular Structure and Dynamics", page 9.

Leonid S. Brown and Vladimir Ladizhansky (University of Guelph) "Pichia pastoris as a Eukaryotic Protein Isotope-Labeling System", pages 14-15.

Ying Fan, Lichi Shi, Vladimir Ladizhansky and Leonid S. Brown (University of Guelph) "Uniform Isotope Labeling of Eukaryotic Proteins in Methylotrophic Yeast for High-Resolution NMR Studies - Extension to Membrane Proteins", Application Note 26, pages 71-74.

Recent research by Gang Wu's group (Queen's University) is cited as an example of advanced 17O NMR spectroscopy in large protein-ligand complexes in solution and in the solid state, "17O NMR reagents", page 34.

These application notes are available for download as a PDF file (5.1MB) "Stable Isotopes for Structural Biomolecular NMR Catalog" at:
http://www.isotope.com/cil/literature/research_literature/index.cfm


Thesis Defenses

Renee Webber (University of Guelph) June 2011

Supervisors: Prof. Glenn Penner

Ph.D. thesis: "An NMR Spectroscopic and Quantum Chemical Investigation of Hydrogen Bonding In Solids"

External Examiner: Prof. Gang Wu (Queen's University)


"Canadian NMR Research" News Bulletin (May 16/11)

Spring 2011

The Spring 2011 Issue of the "Canadian NMR Research" news bulletin featuring the Guest Editorial by James Davis and Vladimir Ladizhansky (University of Guelph) and other Canadian NMR news is now available for download.

You are welcome to share this bulletin with your colleagues and students.


Solid-State DNP-NMR Spectrometer at Guelph (April 12/11)

Bruker has announced that the first commercial 395 GHz solid-state DNP-NMR spectrometer (600 MHz) will be installed at the University of Guelph (read the full press-release).


NMR paper in Angewandte Chemie (Dec 30/10)

L. Shi, I. Kawamura, K.-H. Jung, L.S. Brown, and V. Ladizhansky, "Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment," Angewandte Chemie International Edition (2011) online. http://dx.doi.org/10.1002/anie.201004422


New NMR book (October 4/10)

EMR books
Solid-State NMR Studies of Biopolymers

edited by Anne McDermott, Tatyana Polenova
Hardcover: 592 pages
Publisher: Wiley; September 2010
Language: English
ISBN: 978-0470721223
http://www.amazon.com/dp/0470721227
http://www.amazon.ca/dp/0470721227

Wiley: "The field of solid state NMR of biological samples has blossomed recently, requiring new practitioners in industry and academia to have fundamental understanding of this technology. Discussed are Solid State NMR methods for studying structure dynamics and ligand-binding in biopolymers as well as RF pulse sequences for various applications, including not only a systematic catalog but also a discussion of theoretical tools for analysis of pulse sequences. Including practical examples of biochemical applications, this dependable EMR handbook thoroughly examines a field sure to expand in the years ahead."

Canadian contributions

V. Ladizhansky, "Dipolar-Based Torsion Angle Measurements for Protein Structure Determination," Chapter 14, Solid-State NMR Studies of Biopolymers (EMR Books), Eds. A.E. McDermott and T. Polenova, Wiley (2010) pp. 273-284. http://dx.doi.org/10.1002/9780470034590.emrstm1153

M. Auger, "Structural and Dynamics Studies of Lipids by Solid-State NMR ", Chapter 27, Solid-State NMR Studies of Biopolymers (EMR Books), Eds. A.E. McDermott and T. Polenova, Wiley (2010) pp. 463-472. http://dx.doi.org/10.1002/9780470034590.emrstm1100

Table of Contents and Google preview are available (Wiley).


Canada Research Chairs in magnetic resonance (March 26/10)

Government of Canada has announced today (external link) an investment of $165.5 million to fund 187 new or renewed Canada Research Chairs in 44 Canadian universities. This includes renewal of two Chairs involved in magnetic resonance research.

Gary Shaw (University of Western Ontario) Canada Research Chair Tier 1 in Structural Neurobiology

Vladimir Ladizhansky (University of Guelph) Canada Research Chair Tier 2 in Biophysics

Our sincere congratulations to Gary and Vladimir with this well-deserved recognition.


Thesis Defenses

Lichi Shi (University of Guelph) December 2009

Supervisors: Leonid Brown and Vladimir Ladizhansky

Ph.D. thesis: “Solid-state NMR study of proteorhodopsin in the lipid environment: spectra assignments and structural insights”


Thesis Defenses

Mumdooh Ahmed (University of Guelph) August 2009

Supervisors: George Harauz and Vladimir Ladizhansky

Ph.D. thesis: “Dynamics and Induced Structure of intrinsically disordered myelin proteins by NMR spectroscopy”


Thesis Defenses

Rafal Janik (Protein NMR Research Group, University of Guelph) October 2008

Research supervisor: Vladimir Ladizhansky

M.Sc. thesis: “Development of long-range chemical shift correlation experiments using homonuclear rotary resonance”


Valerie Robertson featured in At Guelph

April 29, 2008

ValerieRead a feature article about Valerie Robertson, an NMR Facility Manager at the University of Guelph, in the April 2008 issue of At Guelph, the University of Guelph's official campus newspaper (external link ).

Photo from: www.uoguelph.ca