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Gang Wu (Department of Chemistry)

Françoise Sauriol (NMR Facility)

NMR facility at Queen's University

Steven Smith (Department of Biomedical and Molecular Sciences/PFD)

Protein Function Discovery (PFD) Research and Training Program

C&EN: Nitroprusside Color Mystery Resolved (Oct 26/15)
Nitroprusside Color Mystery Resolved Y. Gao, A. Toubaei, X. Kong, G. Wu, "Solving the 170-Year-Old Mystery About Red-Violet and Blue Transient Intermediates in the Gmelin Reaction," Chemistry - A European Journal 21 (2015) 17172–17177. (Feature Article) http://dx.doi.org/10.1002/chem.201503353
Chemical & Engineering News Concentrates "Nitroprusside Color Mystery Resolved" Volume 93 (2015), Issue 42, page 23. http://cen.acs.org/articles/93/i42/Nitroprusside-Color-Mystery-Resolved.html

"Canadian NMR Research" News Bulletin (Nov 18/13)Fall 2013

Colleagues and fellow MR-enthusiasts,

we present you the Fall 2013 issue of the "Canadian NMR Research" bulletin (download here), our traditional mix of news and research updates. In this issue Seth Chitayat and Gang Wu report from the recent MOOT gathering in Kingston, Bruker Canada announces online training courses, and the CSC 2014 Conference in Vancouver starts to take shape.

Thanks for reading!

MOOT XXVI NMR Symposium, Kingston, ON, October 25-27, 2013 (Sept 17/13)

MOOT XXVI NMR Symposium registration deadline was extended to September 30, 2013. Please make sure we have your abstract information by then.

In the coming weeks, we will send around a program and will notify those who were selected to give an oral presentation.

If you have any stellar undergraduate students, please put their names forward for an undergraduate travel award to MOOT XXVI in Kingston.

For more information visit http://www.mootnmr.org

Your MOOT XXVI Organizing Committee,

Seth Chitayat and Gang Wu

NMR Workshop at MOOT (Sept 12/13)

Greetings MOOTers,

We are offering a free workshop on NMR data processing (NMRPipe) and analysis (NMRViewJ) on the afternoon of Friday October 25th (3-7 PM). This is a hands-on workshop, attendees will be required to bring their own laptop computer.

If you would like to attend, please e-mail [sameer.wahid "at" mcgill.ca] prior to Friday, September 27th.

Topics include:
- Introduction to NMRPipe and NMRViewJ
- 2D data processing and phasing, with NMRPipe
- Viewing 2D spectra, peak picking, and making figures using NMRViewJ
- Analysis of protein NMR titration data, using NMRViewJ
- Other topics can be covered on request

Best regards,

Sameer Al-Abdul-Wahid
Postdoctoral Fellow - Gehring Lab
McGill University, Department of Biochemistry

For more information about MOOT visit http://www.mootnmr.org

"Canadian NMR Research" News Bulletin (May 14/13)Spring 2013

Colleagues, the Spring 2013 issue of the "Canadian NMR Research" news bulletin is ready for your attention, our traditional mix of news and research updates. In this issue: DNP-NMR at Guelph, 850 MHz at McMaster, and the first MOOT XXVI announcement. You are welcome to share this bulletin with your colleagues and students.

Thesis Defenses (July 24/12)

Irene Kwan (Queen's University) June 25, 2012
Supervisor: Prof. Gang Wu
Ph.D. thesis: "Structural Elucidation of Guanosine Self-Assemblies Using Spectroscopic and Computational Methods"
External Examiner: Prof. Glenn Penner (University of Guelph)

Cover article in the Journal of the American Chemical Society (Dec 7/11)

High-Resolution 39K NMR Spectroscopy of Bio-organic Solids Gang Wu, Zhehong Gan, Irene C. M. Kwan, James C. Fettinger, and Jeffery T. Davis, "High Resolution 39K NMR Spectroscopy of Bio-organic Solids," J. Am. Chem. Soc. 133 (2011) 19570–19573. (cover article) http://dx.doi.org/10.1021/ja2052446

Encyclopedia of Magnetic ResonanceEncyclopedia of Magnetic Resonance: new entries (Sept 20/11)

G. Wu "Oxygen 17 NMR Studies of Organic and Biological Molecules", Encyclopedia of Magnetic Resonance (2011). http://dx.doi.org/10.1002/9780470034590.emrstm1212

D.I. Hoult "Magnetic Resonance with Conducting and High- Dielectric Samples", Encyclopedia of Magnetic Resonance (2011). http://dx.doi.org/10.1002/9780470034590.emrstm1182

Stable Isotopes for Structural Biomolecular NMR Stable Isotopes for Structural Biomolecular NMR (July 22/11)

Cambridge Isotope Laboratories (CIL) made available a series of application notes on the use of stable isotopes in Biomolecular NMR. These application notes were written by some of the world's leading researches in the field, including several Canadian scientists.

Lewis Kay (University of Toronto) "Alanine Probes of Supra-Molecular Structure and Dynamics", page 9.

Leonid S. Brown and Vladimir Ladizhansky (University of Guelph) "Pichia pastoris as a Eukaryotic Protein Isotope-Labeling System", pages 14-15.

Ying Fan, Lichi Shi, Vladimir Ladizhansky and Leonid S. Brown (University of Guelph) "Uniform Isotope Labeling of Eukaryotic Proteins in Methylotrophic Yeast for High-Resolution NMR Studies - Extension to Membrane Proteins", Application Note 26, pages 71-74.

Recent research by Gang Wu's group (Queen's University) is cited as an example of advanced 17O NMR spectroscopy in large protein-ligand complexes in solution and in the solid state, "17O NMR reagents", page 34.

These application notes are available for download as a PDF file (5.1MB) "Stable Isotopes for Structural Biomolecular NMR Catalog" at:

Review in Progress in Nuclear Magnetic Resonance Spectroscopy (June 13/11)

progress Gang Wu and Jianfeng Zhu "NMR studies of alkali metal ions in organic and biological solids," Progress in Nuclear Magnetic Resonance Spectroscopy (2011) accepted. (Invited Review) http://dx.doi.org/10.1016/j.pnmrs.2011.06.002

ACCN: 17O NMR Discovery (March 4/11)

ACCN the Canadian Chemical News, March, 2011
Latest News: New NMR Technique Solves Oxygen Puzzle (online)
(print, ACCN, Volume 63, Number 3, p. 9)

C&EN News of the Week: Elevating Oxygen (Jan 3/11)

Two recent NMR papers by Gang Wu (Queen's) and coworkers are highlighted by Chemical & Engineering News in their first issue of 2011.


Both papers deal with 17O NMR in large protein complexes, in solution and in solid state. New research approaches proposed by Gang Wu and his team have a potential to significantly advance the field of protein NMR spectroscopy.

Jianfeng Zhu and Gang Wu, "Quadrupole Central Transition 17O NMR Spectroscopy of Biological Macromolecules in Aqueous Solution," Journal of the American Chemical Society 133 (2011) ASAP. http://dx.doi.org/10.1021/ja1079207

Jianfeng Zhu, Eric Ye, Victor Terskikh, and Gang Wu, "Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes," A
ngewandte Chemie International Edition 49 (2010) 8399-8402. (Cover Article) http://dx.doi.org/10.1002/anie.201002041

Part of this research was made possible using resources of the National Ultrahigh-Field NMR Facility for Solids. See the complete list of research publications enabled by the Facility here (complete list).

Cover article in Angewandte Chemie (Nov 18/10)


Low concentration and poor sensitivity often hinder or make impossible solid-state 17O NMR in large biomolecular systems. In this cover article in Angewandte Chemie Gang Wu (Queen’s) and co-workers from the University of Ottawa and NRC Canada show that at an ultrahigh magnetic field of 21 T the high quality solid-state 17O NMR spectra can be obtained for large protein–ligand complexes of up to 300 kDa in size. Complementary multinuclear 17O, 27Al, and 13C NMR data obtained in this work have aided in the structural refinement for an ovotransferrin bound Al-oxalate complex.

Jianfeng Zhu, Eric Ye, Victor Terskikh, and Gang Wu, "Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes," Angewandte Chemie International Edition 49 (2010) 8399-8402. (Cover Article) http://dx.doi.org/10.1002/anie.201002041

Softpedia, November 18, 2010
Molecular Oxygen Studies Targeted by New Tool

Queen's University News Center, November 17, 2010
Scientists discover new method for studying molecules

This is an ninth cover article featuring results obtained using resources of the National Ultrahigh-Field NMR Facility for Solids. See our cover gallery and the complete list of research publications enabled by the Facility here (complete list).

900 Facility Steering Committee membership (June 1/10)

The National Ultrahigh-Field NMR Facility for Solids wishes to extend its sincere thanks to Yining Huang (Western), the outgoing member of the Facility Steering Committee who served in 2006-2010. Yining has done a great job as the representative for Ontario Universities. His valuable insights and suggestions have certainly helped to improve the Facility and broaden its userbase.

The Facility is pleased to announce that Gang Wu (Queen's) has been appointed to serve on the Facility Steering Committee as the representative for Ontario Universities for the next three years. Gang Wu is a long-time facility user and his first-hand experience will be very useful in managing the Facility. Welcome aboard, Gang!

To contact members of the Facility Steering Committee

ICASS 2009 (September 11/09)

Summer 2009
The front page of the Summer 2009 issue of the "Canadian NMR Research" news bulletin features a news report about a special NMR symposium in honour of Professor Rod Wasylishen which was held during the 55th International Conference on Analytical Sciences and Spectroscopy (ICASS) at Queen’s University on August 9-12, 2009. The symposium was organized by Gang Wu and was attended by more then 50 of Rod's colleagues and friends. Read more here.

PCCP themed issue: Solid-State NMR spectroscopy (August 4/09)

chem comm

This high-profile special issue of PCCP guest-edited by Paul Hodgkinson (Durham, UK) and Stephen Wimperis (Glasgow, UK) will be presented to the participants of the upcoming 6th Alpine Conference on Solid-State NMR in September 2009 (conference web-site). Among many excellent reviews and research papers highlighting recent trends and progress in the field of solid-state NMR spectroscopy there are four by Canadian researchers, including the front cover article by Gang Wu's group from Queen's.

Physical Chemistry Chemical Physics, volume 11, issue 32, 2009

Pedro M. Aguiar, Michael J. Katz, Daniel B. Leznoff and Scott Kroeker, "Natural abundance 13C and 15N solid-state NMR analysis of paramagnetic transition-metal cyanide coordination polymers," Physical Chemistry Chemical Physics 11 (2009) 6925-6934. (Invited Article, Themed Issue) http://dx.doi.org/10.1039/b907747b

Jianfeng Zhu, Amanda J. Geris and Gang Wu, "Solid-state 17O NMR as a sensitive probe of keto and gem-diol forms of alpha-keto acid derivatives," Physical Chemistry Chemical Physics 11 (2009) 6972-6980. (Cover Article, Themed Issue) http://dx.doi.org/10.1039/b906438a

Rebecca P. Chapman and David L. Bryce, "Application of Multinuclear Magnetic Resonance and Gauge-Including Projector-Augmented Wave Calculations to the Study of Solid Group 13 Chlorides," Physical Chemistry Chemical Physics 11 (2009) 6987-6998. (Invited Article, Themed Issue) http://dx.doi.org/10.1039/b906627f

Luke A. O'Dell and Robert W. Schurko, "Static solid-state 14N NMR and computational studies of nitrogen EFG tensors in some crystalline amino acids," Physical Chemistry Chemical Physics 11 (2009) 7069-7077. (Invited Article, Themed Issue) http://dx.doi.org/10.1039/b906114b

ICASS 2009 : First announcement (Feb 25/09)

The 55th International Conference on Analytical Sciences and Spectroscopy (ICASS) will be held at Queen’s University (Kingston, Ontario, Canada) on August 9-12, 2009. The conference will feature a special NMR Symposium in honour of Professor Rod Wasylishen.

The conference will also have a fantastic social program including the Magical Dinner with Canada's Magic Champion Eric Leclerc and a very popular Sunset Dinner Cruise of the Thousand Islands.

The abstract submission for oral and poster presentations is now open and will last until June 1, 2009.

ICASS offers a special discount for early bird registration which is available until April 1, 2009.

Please check the ICASS conference website for details: http://www.icass.ca/2009/

Or contact the NMR Symposium organizer, Gang Wu, for more information

C&EN News of the week: Nucleotide self-assembly (Feb 16/09)5'-GMP

Recent JACS Communication by Gang Wu and Irene Kwan (Wu's group, Queen's University) is highlighted as News of the week in Chemical & Engineering News as an important contribution to our understanding of self-assembly of nucleotide monomers. In their research Gang and Irene have used a variety of liquid-state NMR techniques and computations to characterize guanosine 5'-monophosphate (5'-GMP) solutions in the presence of sodium cations. The authors have observed spontaneous formation of well-defined right-handed helical 5'-GMP structures, the finding which may have potential implications for prebiotic chemistry theories.

Read the news story in C&EN (picture credit)
Issue February 16, 2009, p.10, News of the week:

G. Wu and I. Kwan, "The helical structure of disodium guanosine 5’-monophosphate self-assembly in neutral solution," Journal of the American Chemical Society 131 (2009) 3180–3182. http://dx.doi.org/10.1021/ja809258y

Recognition: Gang Wu (August 20, 2008)

Join us in congratulating Gang Wu (Queen's University) who has been promoted to the rank of Professor !

At Queen's Department of Chemistry Prof. Gang Wu carries out an extensive research program in Physical and Computational chemistry involving solid-state NMR. Gang Wu is also a frequent user of the 900 NMR Facility in Ottawa.

web: http://www.chem.queensu.ca/people/faculty/Wu/index.htm

Photo from : http://www.chem.queensu.ca

"One of Canada's leading universities with an international reputation for scholarship, research, social purpose, spirit, and diversity, Queen's is also well-known for its incomparable 24-hour learning environment. The Queen's experience combines great teaching, people, and tradition on a campus with a global reputation in the heart of a vibrant community. Queen's is a university that can bring out the best from inside of you."

"Queen's is one of Canada's leading research-intensive universities. Queen's researchers are conducting innovative studies across a broad spectrum of disciplines from the humanities and social sciences to the physical, natural, and applied sciences."