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Pedro Aguiar (NMR Chemistry)

Michel Lafleur (Chemistry) (Group website)

Pascale Legault (Biochimie) (Group website)

James Omichinski (Biochimie)

Michael Osborne (IRIC NMR)

Julian X. Zhu (Chemistry) (Group website)

Regional Centre of NMR spectroscopy

Institut de recherche en immunologie et en cancérologie (IRIC) (English)

CanadianManager - Structural Biology Facility, Department of Biochemistry and Molecular Medicine, Université de Montréal (April 25/17)

General description

As a structural biology specialist (NMR spectroscopy and X-ray crystallography), you will be responsible for optimal usage of a new structural biology facility at UdeM under the direction of the professor responsible for the facility and in close collaboration with members of the department. Your duties will include user training, equipment operation and maintenance as well as development of experimental protocols associated with research projects and academic training.

Main duties
• Provide user training and oversee instrument usage of all the equipment within the structural biology facility (500 MHz, 600 MHz, and 700 MHz NMR spectrometers, liquid handling robots, stereomicroscopes, crystallisation chambers, light-scattering equipment (MALS/RI), etc)
• Assure the optimal operation of equipment and offer technical assistance when needed
• Assure the maintenance of the structural biology equipment
• Develop and implement protocols for instrument maintenance, data collection and analysis, both in French and English
• Contribute to budget planning for the facility and to purchasing consumables and new equipment
• Collaborate with departmental staff for planning of instrument schedule, billing, and maintenance of a web page describing the facility
• Participate in the development of didactic material for teaching undergraduate and graduate students
• Serve as a resource for users, providing expert advice in experiment planning and data analysis
• Coordinate with manufacturers for preventive maintenance and repairs
• Maintain professional and technical knowledge
• Promote the facility
• Ensure the safety of users and personnel who have access to the facility

Skills and qualifications

Required education and experience:
• Applicants must have a MSc and three (3) years of relevant experience or PhD degree in Chemistry, Biochemistry or related discipline

Preferred qualifications:
• Experience in structural biology, especially in NMR spectroscopy and X-ray crystallography
• Experience in using computer software and developing computer scripts for structural biology applications
• Oral and written communication skills, both in French and English
• Experience in instrument maintenance and repair
• Demonstrated ability to train students
• Other qualifications: autonomy, scientific rigor, sense of organization, capacity for teamwork

More information
• Salary scale (hourly) : $27.36 to $39.31
• Supervisor: Pascale Legault, Professor, Department of Biochemistry and Molecular Medicine
• Location : Roger-Gaudry Building, Université de Montréal, Montreal, Quebec, Canada
• Working hours: Monday to Friday, 9h00 to 17h00

Please send a curriculum vitae listing all publications and a list of three references as well as a cover letter to: [ pascale.legault "at" umontreal.ca ]

Pascale Legault, Ph.D.
Département de Biochimie et Médecine Moléculaire
Université de Montréal
Tel: 514-343-7326
E-mail: pascale.legault "at" umontreal.ca
URL: http://airen.bcm.umontreal.ca

CanadianPostdoctoral Fellowship in protein NMR, University of Montreal (July 28/15)

We have a position for a postdoctoral fellow with protein NMR experience. The position is in Dr Katherine Borden’s laboratory at the Institute for Research in Immunology and Cancer at the University of Montreal
( http://www.iric.ca ) and will focus on novel areas of RNA metabolism that are related to cancer.

Successful candidates should have experience expressing and purifying proteins as well as experience in routine protein NMR methods. Experience in other biophysical methods for characterizing protein:protein and protein:RNA interactions will be beneficial.

Candidates should not be more than 2 years since obtaining their PhD. PhD students who are nearing graduation may also apply. Salary will be commensurate with experience. Interested parties should apply to [bordenlabjobs "at" gmail.com]

NSERC 2014 Competition Results (June 27/14) [NSERC  ]

Discovery Grants

Blaine Chronik (Western) Magnetic Resonance Systems Development

Kalle Gehring (McGill) Protein folding in the endoplasmic reticulum

Paul Hazendonk (Lethbridge) Solid-State NMR of Complex Hybrid Organic-Inorganic Materials

Vladimir Ladizhansky (Guelph) Interactions of membrane proteins with lipids, water, and other proteins in biological membranes

William MacFarlane (UBC) Development and Application of Depth-Resolved beta-Detected Nuclear Magnetic Resonance to electronic, ionic and molecular phenomena in the Solid State

Giuseppe Melacini (McMaster) Solution NMR Studies of Interactions of Ligands With Plasma Proteins

Anthony Mittermaier (McGill) Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions

Geoffrey Ozin (Toronto) Silicon Nanochemistry

Linda Reven (McGill) Solid-State NMR of Polymer and Liquid Crystalline Nanocomposites

Andre Simpson (Toronto Scarborough) Development of flow-based and magic angle spinning in-vivo NMR to understand environmental stress

Jenifer Thewalt (Simon Fraser) Domains in Biologically Relevant Lipid Membranes

David Wishart (Alberta) Development of Improved Methods to Rapidly Characterize Protein Structure, Function and Dynamics

Julian Zhu (Université de Montréal) Versatile Polymeric Biomaterials

Discovery Accelerator Supplement
$120,000 over three years

Giuseppe Melacini (McMaster) Solution NMR Studies of Interactions of Ligands With Plasma Proteins

Research Tools and Instruments (RTI)

Derek Gates (UBC) Upgrade to UBC-Chemistry Departmental NMR Facility

Cover article in ChemMedChem (Feb 22/13)

Binding of HIV-1 Capsid Assembly Inhibitors

N. Goudreau, R. Coulombe, A.-M. Faucher, C. Grand-Maitre, J.-E. Lacoste, C.T. Lemke, E. Malenfant, Y. Bousquet, L. Fader, B. Simoneau, J.-F. Mercier, S. Titolo, and S.W. Mason, "Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using 19F Ligand-and 15N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series," ChemMedChem 8 (2013) 405–414. (Cover Article) http://dx.doi.org/10.1002/cmdc.201200580

Recognition: Julian Zhu (April 29/12)

Polymer Chemistry (RSC) profiles Prof. Julian Zhu (Université de Montréal) as the author of the week.

New NMR book (Oct 29/11)

NMR Spectroscopy of Polymers

NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules
ACS Symposium Series, Volume 1077

Editors: H.N. Cheng, T. Asakura, A.D. English
Publisher: ACS, October 2011
Language: English
ISBN: 978-0841226678

This ACS Symposium Series book includes papers presented at the Symposium "NMR Spectroscopy of Polymers - Innovative NMR Strategies for Complex Macromolecular Systems" which was part of Pacifichem 2010, the 2010 International Chemical Congress of Pacific Basin Societies in Honolulu, Hawaii, December 15-20, 2010. Among over 30 contributions on the state-of-the-art NMR spectroscopy in polymers and related systems there are two chapters by Canadian NMR research groups.

P.M. Macdonald, "Diffusion NMR of Polymers in Bicelles," Chapter 14, NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules, Eds. H.N. Cheng, T. Asakura, A.D. English, ACS (2011) pp. 221-250. http://dx.doi.org/10.1021/bk-2011-1077.ch014

H. Thérien-Aubin, Y.J. Wang, and X.X. Zhu, "NMR Imaging and Its Application in the Study of Pharmaceutical Tablets," Chapter 27, NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules, Eds. H.N. Cheng, T. Asakura, A.D. English, ACS (2011) pp. 441-457. http://dx.doi.org/10.1021/bk-2011-1077.ch027

CREATE program in Bionanomachines (July 23/11)

The Natural Sciences and Engineering Research Council of Canada (NSERC)
has announced a new Collaborative Research and Training Experience (CREATE) grant in Bionanomachines led by Kalle Gehring at McGill University.

The CREATE Program in Bionanomachines (CTPB) is focused on the principles, design, and applications of bionanomachines, which are defined as nanometer scale devices such as enzymes or biomaterials that are derived from living organisms and composed of DNA, RNA, protein, sugars, and/or lipids. Existing bionanomachines touch us every day as improved stain-removing enzymes in laundry detergents to diagnostic tools and therapies for medicine and health.

The CTPB links world-class laboratories from across Canada in the fields of structural biology, biotechnology, supramolecular chemistry, nanotechnology, biophysics and protein engineering. Summer and graduate studentships can be held at Concordia University, the Université Laval, McGill University, the University of Calgary, the Université de Montréal, and the Université du Québec à Montréal. Applications for next year are due in December 2011.

A full list of mentors and program details can be found on the CTPB web site: http://www.bionano.ca/ or by e-mail (bionanomachines.med "at" mcgill.ca)

NMR events at CSC 2011 (Jan 26/11)

Dear colleagues,

The 94th Canadian Chemistry Conference and Exhibition (CSC 2011) "Chemistry and Health" will be held in Montréal, Québec from June 5-9, 2011, as a joint effort of the Canadian Society for Chemistry and the four Montréal Universities, with the Université de Montréal Chemistry Department as the host. The CSC is the largest annual national event for chemical professionals attracting close to 2500 participants each year.

Canada is very dynamic in Nuclear Magnetic Resonance spectroscopy and to pursue the tradition, a solid-state NMR workshop as well as two 1.5-day NMR symposia are scheduled to cover a wide range of applications and developments in the fields of solution and solid-state NMR.

Profs Anthony Mittermaier (McGill University) and Pierre Lavigne (Université de Sherbrooke) are organizing the "Solution NMR: Biomolecular structure, dynamics, and function" symposium which includes, amongst a list of over 15 speakers, Charalampos Kalodimos (Rutgers U.). Brian Sykes (U. of Alberta), Gary Shaw (U. Western Ontario) and Lawrence McIntosh (UBC).

Profs Michel Lafleur (Université de Montréal) and Isabelle Marcotte (Université du Québec à Montréal) are co-organizers of the symposium entitled "Solid-state NMR: From materials to biomolecules". So far, Profs Marc Baldus (U. of Utrecht), Vladimir Ladizhansky (U. of Guelph), Bruce Balcom (U. New Brunswick), Valerie Booth (Memorial U.) and Dr. Ansgar Siemer (Columbia U.) have confirmed their presence as guest speakers.

We invite you to participate in the CSC2011 conference which plenary lecturer will be Nobel Laureate Prof. Roger Tsien (U. of California, San Diego). More detail on the symposia, abstract submission and registration can be found on the conference website at http://www.csc2011.ca

The deadline for abstract submission is February 15, 2011.

Submit your abstract through Hermes Conference Centre via the CSC2011 website. Details are available at http://www.csc2011.ca/Program/submit_abstract.html

NMR Symposia Organizers

Canada Research Chairs in magnetic resonance (Nov 25/10)

Government of Canada has announced (external link) an investment of $275.6 million to fund 310 new or renewed Canada Research Chairs at 53 Canadian universities.
This includes renewal of four Chairs involved in magnetic resonance research.

Cheryl Arrowsmith (University of Toronto) Canada Research Chair Tier 1 in Structural Proteomics

Mitsuhiko Ikura (University of Toronto) Canada Research Chair Tier 1 in Cancer Structural Biology

Pascale Legault (Université de Montréal) Canada Research Chair Tier 2 in Structural Biology and Engineering of RNA

Josef Zwanziger (Dalhousie University) Canada Research Chair Tier 1 in the Nuclear Magnetic Resonance Studies of Materials