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Peter
Macdonald (Chemistry, Mississauga) 
Scott
Prosser (Chemistry, Mississauga)
Andre
Simpson (Chemistry,
Scarborough)
Myrna
Simpson (Environmental Science, Scarborough)
Lewis
Kay (Biochemistry)
Cheryl
Arrowsmith (Ontario Cancer Institute)
Mitsu
Ikura (Medical Biophysics UofT, Ontario Cancer Institute)
Julie
Forman-Kay (SickKids)
Simon
Sharpe (SickKids)
Genevieve
Seabrook (NMR Facility, Ontario Cancer Institute)
Tim
Burrow (CSICOMP, Chemistry)
CSICOMP
(Chemistry)
Postdoctoral position, University of Toronto Mississauga (August
14/10)
A
postdoctoral position is available for a Canadian Institutes of Health Research
funded project in the laboratory of Professor Voula Kanelis at the
University of Toronto Mississauga (UTM). The successful candidate will investigate
the nucleotide binding domains (NBDs) of the sulfonyl urea receptors (SURs)
using biophysical approaches, including NMR spectroscopy. SUR proteins are
ABC transporters that form the regulatory subunits of ATP-sensitive potassium
(KATP) channels. We are studying the effects of disease-causing mutations
in the SUR NBDs on their stability, structure, and interactions with other
regions in the SURs and in KATP channels. A Ph.D. in biochemistry or a related
discipline is required. Candidates should have experience with protein expression
and purification and protein NMR spectroscopy.
Located 30 km west of downtown Toronto, The University of Toronto Mississauga
(www.utm.utoronto.ca)
is a campus of the University of Toronto (www.utoronto.ca),
the largest research University in Canada. UTM provides all of the advantages
of research at the University of Toronto, while additionally providing a smaller,
friendly campus environment in a beautiful natural setting by the Credit river.
Our newly renovated and well-equipped laboratory contains all the equipment
necessary for protein biochemistry and fluorescence spectroscopy. Other equipment
(CD spectrophotometer, isothermal titration calorimeter, differential scanning
calorimeter) is available in the Center for Applied Bioscience and Biotechnology
at the University of Toronto Mississauga. NMR experiments will be performed
primarily on a Varian 600 MHz spectrometer equipped with a cryoprobe at UTM.
We also have access to high-field spectrometers located at the University
of Toronto NMR facility.
Interested applicants should submit their CV, contact information for three
references, and a description of previous research experience to Voula
Kanelis (voula.kanelis "at" utoronto.ca).
NMR
Scientist at the Environmental NMR Centre, University of Toronto Scarborough
(August 10/10)
The Environmental NMR Centre and the Department of Physical and Environmental Sciences at the University of Toronto Scarborough are seeking a Senior NMR Research Associate to oversee the daily operation, training, and management of the Environmental NMR Centre. The position has a very large research and development component and the candidate is expected to work closely in and with the facilities Directors to maintain the centre at the cutting-edge of Environmental NMR globally and be central to pioneering new developments in NMR in general.
The Environmental NMR Centre currently houses two unique, Bruker BioSpin NMR systems. The first is a fully hyphenated 2D-HPLC-SPE-NMR-MS, and is novel both in Canada and Environmental Research in general. The second system has capabilities to perform in situ multiphase NMR analyses of heterogeneous samples that contain solid, gel and solution phase samples, the hardware is globally unique and being co-developed directly with Bruker BioSpin. The Centre focuses on the development and application of NMR techniques to study a range of environmental problems. The current topics of research include: environmental metabolomics, LC-SPE-NMR-MS applications to complex environmental mixtures, in vivo NMR spectroscopy imaging, hyperpolarization, DNP, development of multiphase NMR methods (solids, HR-MAS, solutions NMR as a single technique). In addition, the Centre focuses on the development and application of novel NMR approaches to complex systems (including soils, ocean sediments, atmospheric deposits (particles, rain, snow, glacial ice), cells, tissues, small organisms and other environmental matrices) to better understand structure and environmental reactivity.
After an initial probationary period, this will be a continuing full-time appointment.
The NMR scientist will report to the Chair of the Department and work closely with the Director and Associate Director of the Environmental NMR Centre. The research associate will be responsible for instrument maintenance, training of graduate students/postdoctoral fellows/visiting scientists assist in writing grant applications to upgrade the centre and co-publication of research with the facility's principal investigators and collaborators. The candidate will also be expected to lead research projects publishing both as a primary and secondary author. The successful candidate will take an active role in all aspects of the research of the NMR Centre and will strive to ensure that he/she becomes recognized as a leader in the field of Environmental NMR spectroscopy.
The candidate will also be involved in undergraduate thesis supervision in the Department's chemistry program and will be encouraged to apply to instruct one course in the undergraduate chemistry program on a yearly basis. The candidate will also oversee the operation/maintenance of a teaching/research Departmental NMR system (Bruker BioSpin 500MHz Avance) and ensure that faculty and students can acquire high quality data required for the teaching and research programs. These duties will include the set up of new experiments, training of students/faculty, maintenance and calibration. Candidates should note that the departmental NMR system is fully automated (BACS) with a single automatic tuning and matching probe (ATM) and that the department has only a small number of users, once running smoothly should require minimal intervention on a daily basis.
Applicants must have a Ph.D. in Chemistry or related discipline with a very strong background in NMR spectroscopy and a drive/passion for the development of NMR spectroscopy. In exceptional circumstances, an established leader in the field with a MSc degree but more than 10 years of experience may be considered. In addition, experience with metabolomics, chromatography, mass spectrometry and working with complex biological and/or environmental systems are a strong assets. Experience with pulse programming, custom processing of NMR data (MATLAB, ACD, etc.) and programming/webpage design is also beneficial. Experience with Bruker instruments is very important and the ideal candidate will have experience in (or enthusiastic to learn) all areas of NMR including solutions, HR-MAS, solids and imaging.
Salary
will be commensurate with the candidate's qualifications and experience.
Applicants should send a cover letter, curriculum vitae, a statement of research,
a statement of teaching and three letters of reference to:
Rose
Jones (Assistant to the Chair)
NMR Scientist Search Committee
Department of Physical & Environmental Sciences
University of Toronto Scarborough
1265 Military Trial
Toronto, Ontario M1C 1A4
Email submissions should be sent to: rjones "at" utsc.utoronto.ca
Unfortunately, applications that are not accompanied by at least three references cannot be considered.
We will start reviewing applications beginning September 13, 2010, although the search will remain open until the position is filled.
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, members of sexual minority groups, and others who may contribute to the further diversification of ideas.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.
the
Department of Physical and Environmental Sciences, UTSC
http://www.utsc.utoronto.ca/~physsci/
Andre
Simpson's Environmental research group
http://www.utsc.utoronto.ca/~asimpson/
Myrna
Simpson's Research Group in Environmental Chemistry
http://www.utsc.utoronto.ca/~msimpson/
 |
Multidimensional
NMR Methods for the Solution State
edited by Gareth A. Morris and James W. Emsley Hardcover: 580 pages Publisher: Wiley; June 2010 Language: English ISBN: 978-0470770757 http://www.amazon.com/dp/0470770759 http://www.amazon.ca/dp/0470770759 |
Wiley: "Multidimensional NMR methods have transformed the way in which solution state NMR is used to elucidate the structures of chemical and biochemical systems. The first book covering new developments in nearly a decade, this much-needed resource explains recent experimental methods for the rapid measurement of multidimensional solution-state NMR spectra. With articles written by key developers of the techniques, the coverage deals with both the theoretical tools and the latest practical applications, giving an unmatched guide to students, researchers, technicians, and anyone else working with NMR techniques today"
Canadian contributions
A.D. Bain "COSY: Quantitative Analysis," Chapter 13, Multidimensional NMR Methods for the Solution State (EMR Books), Eds. G.A. Morris and J.W. Emsley, Wiley (2010) pp. 167-176. http://dx.doi.org/10.1002/9780470034590.emrstm0095
T.T. Nakashima and R.E.D. McClung "Heteronuclear Shift Correlation Spectroscopy," Chapter 22, Multidimensional NMR Methods for the Solution State (EMR Books), Eds. G.A. Morris and J.W. Emsley, Wiley (2010) pp. 289-304. http://dx.doi.org/10.1002/9780470034590.emrstm0209
R. Muhandiram and L.E. Kay "3D HMQC-NOESY, NOESY-HMQC, and NOESY-HSQC," Chapter 25, Multidimensional NMR Methods for the Solution State (EMR Books), Eds. G.A. Morris and J.W. Emsley, Wiley (2010) pp. 335-350. http://dx.doi.org/10.1002/9780470034590.emrstm0563
The complete Table of Contents is available on Stan's NMR blog.
Attenuator
app for iPhone/iPod touch (April 29/10)
Tim
Burrow (University of Toronto) wrote a utility application for the
iPhone/iPod touch that calculates attenuation values:
http://itunes.apple.com/ca/app/attenuator/id367216554
Attenuator is a utility for anyone working with radio frequency sources and needs to know power and voltage after attenuation.
You can specify an input voltage (Vpp or Vrms) and dB of attenuation to get the output voltage, power and attenuation. The impedance can be specified, typically 50 Ohm for most systems.
This
free application is available in English, French, Chinese and Japanese and
is sponsored by Open Technologies.
For more information visit: http://www.attenuator.ca/
Natural Sciences and Engineering Research Council of Canada (NSERC) has announced results of the 2010 NSERC competition in the Discovery Grants Program (DG), Research Tools and Instruments Grants (RTI) and Scholarship programs. Among grant recipients
Myrna Simpson's (University of Toronto Scarborough) NSERC Discovery Grant was renewed. Myrna has also been awarded an NSERC Discovery Accelerator Supplement.
Share your success with the Canadian NMR community (E-mail).
Postdoctoral position in biological solid-state NMR
Postdoctoral positions in biomolecular solid state NMR are available at The Hospital for Sick Children. These positions will focus on structure determination and dynamic characterization of protein and peptide assemblies by solid state NMR, with an emphasis on systems relevant to human health and disease. Ongoing projects include structural studies of oligomeric states of mammalian prion proteins, membrane interactions of amyloid peptides, and structure determination of integral membrane complexes that play a key role in HIV-1 infection. These projects are highly multidisciplinary in nature, and will provide candidates with the opportunity to learn a broad range of biophysical techniques, in addition to NMR, and to collaborate with a number of other research groups.
http://www.sickkids.ca/Research/Sharpe-lab/index.html
Our lab is located within the Molecular Structure and Function Program at the Hospital for Sick Children and the Department of Biochemistry at the University of Toronto, providing a diverse and stimulating research environment. We are fully equipped for cloning, mutagenesis, protein expression and purification, with access to peptide synthesis, computational biology facilities and full-time use of a 500 MHz spectrometer for solids MAS and static experiments. In addition, access to the National 900 MHz NMR facility in Ottawa is also available for most projects.
Highly motivated candidates are sought, who must possess a PhD with a strong track record of scientific productivity, and who should have extensive experience in either biological NMR (solution or solid state) or protein biophysics and structure determination. The start date for this position is negotiable, but is available immediately.
Qualified candidates should send a complete CV to ssharpe "at" sickkids.ca and arrange for 3 letters of reference to be sent to:
Simon
Sharpe
Scientist, Molecular Structure and Function Program
The Hospital for Sick Children
Assistant Professor, Dept. of Biochemistry
University of Toronto
555
University Ave,
Toronto, Ontario
Canada M5G 1X8
Email: ssharpe "at" sickkids.ca
).The Canada Foundation for Innovation (CFI) has announced today major investment in Canadian Research Infrastructure. More than $665 million was awarded to 133 projects at 41 Canadian research institutions through the CFI’s Leading Edge Fund and New Initiatives Fund. Among infrastructure projects receiving Government's support is the Canada's first 950 MHz NMR spectrometer at the University of Toronto (Lewis Kay, Biochemistry) to enable studies of the structure and dynamics of complex biological molecules, as well as the technological development of biological NMR.
Project title: "High Field NMR Studies of Protein Molecules in Health and Disease" (CFI contribution $4,595,843)
This very significant hardware acquisition will ensure Canada's leading role
in biological NMR research.
Congratulations are due to Lewis Kay and his team at the UofT !
A complete list of awarded projects (CFI
web-site)
Lewis Kay and colleagues from the University of Toronto have published an article in Biophysical Journal reviewing recently developed NMR relaxation dispersion technique and its applications to protein folding research.
P.
Neudecker, P. Lundström, L.E. Kay, "Relaxation Dispersion NMR
Spectroscopy as a Tool for Detailed Studies of Protein Folding," Biophysical
Journal 96 (2009) 2045-2054. (review)
http://dx.doi.org/10.1016/j.bpj.2008.12.3907
This review and all previous issues of Biophysical Journal are available free of charge until April 5, 2009. The free access is provided by Cell Press, who is taking over publishing Biophysical Journal starting in 2009.
A research team from the Ontario Cancer Institute and the University of Toronto has developed a real-time, nuclear magnetic resonance (NMR)–based assay to monitor the intrinsic GTPase activity of the small guanosine triphosphatase (GTPase) Rheb. This method can now be used to gain further understanding of the mechanisms of action of other GTPases and their GAP partners.
C.B. Marshall, J. Ho, C. Buerger, M.J. Plevin, Guang-Yao Li, Z. Li, M. Ikura, and V. Stambolic, "Characterization of the Intrinsic and TSC2-GAP–Regulated GTPase Activity of Rheb by Real-Time NMR," Science Signaling 2 (#55) (2009) ra3. http://dx.doi.org/10.1126/scisignal.2000029
Abstract: http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/55/ra3
Editor's
summary:
http://stke.sciencemag.org/cgi/content/summary/sigtrans;2/55/ra3
Science Signaling is a weekly AAAS journal as well as an online resource and information management tool that enables experts and novices in cell signaling to find, organize, and utilize information relevant to processes of cellular regulation. As of September 2008, Science Signaling is adding original research articles to the weekly journal. Science Signaling publishes research that represents a major advance in cell signaling, including key research papers in the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery.
More
about Science Signaling:
http://stke.sciencemag.org/about/
A research team from the University of Toronto Scarborough led by Myrna Simpson reports an accelerated rate of decomposition of some soil organics and accumulation of others due to soil warming.
X. Feng, A.J. Simpson, K.P. Wilson, D.D. Williams and M.J. Simpson, "Increased cuticular carbon sequestration and lignin oxidation in response to soil warming," Nature Geoscience (2008) online. http://dx.doi.org/10.1038/ngeo361
This paper has generated considerable media attention including a feature interview "Soil Alert" with Myrna on Daily Planet (aired on Nov 27, 2008).
https://webapps-new.utsc.utoronto.ca/
http://www.spectroscopynow.com/
http://www.discoverychannel.ca/
web : Myrna Simpson's Group (external link)
Nanochemistry:
A Chemical Approach to Nanomaterials
Authors
Geoffrey A. Ozin, Andre C. Arsenault and Ludovico Cademartiri
Hardcover: 770 pages
Publisher: Royal Society of Chemistry; 2nd Revised edition (January
2009)
Language: English
ISBN-10: 184755895X
ISBN-13: 978-1847558954
RSC: “… The global success of the 1st edition of "Nanochemistry",
and exceptionally rapid change in the field, has necessitated the publication
of a 2nd edition after only three years. This truly major update highlights
the latest breakthroughs using over 80 new case histories, more problem sets,
and more teaching principles. Written for teachers and students, the book
catapults the reader to the forefront of the field. Using simple language,
and focusing on the concepts, it covers all chemistry techniques commonly
used to synthesize nanomaterials. In this book, case histories enable readers
to 'connect the dots' and understand the possibilities ahead whilst problem
sets encourage students to think creatively and laterally about what they
have learnt. The extensive bibliography will satisfy those hungry for more
detail.”
http://www.amazon.com/gp/product/184755895X/
web: Geoffrey Ozin (University of Toronto)