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Current Research Projects

Opened in the Fall of 2005 the 900 NMR Facility has supported over 100 research projects from the academic and government science research communities from Canada and abroad, resulting in more than 170 peer-reviewed research publications. Here is a selection of the most recent and ongoing research projects. To see 2005-2012 research projects please refer to Annual Reports

Biostructural chemistry, natural products, pharmaceuticals and health

Nanostructured materials, electronics and energy storage

Catalysts, porous materials and minerals

Advanced materials research and NMR techniques development


Outlines available for selected projects will open in a new window as a PDF file (50-150 kB).

Biostructural chemistry, natural products, pharmaceuticals and health

2H NMR Study of the Insertion of the Myristoyl Group of Neuroral Calcium Sensor Proteins in Lipid Bilayers
G. Valois-Paillard, C. Salesse, M. Auger
Université Laval, Québec, Québec

Solid-State 17O NMR Studies of Enzyme-Inhibitor Complexes (outline)
J. Zhu, J. Leake, G. Wu
Queen's University, Kingston, Ontario

Applications of Ultrahigh-Field NMR in Solid State for Pharmaceutical Research (outline)
A. Brinkmann (a), V. Terskikh (a), G. Enright (a), J. Ripmeester (a,b)
(a) National Research Council Canada, Ottawa, Ontario
(b) Department of Chemistry, Carleton University, Ottawa, Ontario

Calcium-43 Chemical Shift Tensors as Spectroscopic Probes of Inorganic and Bioinorganic Systems (outline)
C. Widdifield and D. Bryce
University of Ottawa, Ottawa, Ontario

High-resolution 17O-1H correlation solid-state NMR spectroscopy
(outline)
A. Brinkmann (a), X. Kong (b), G. Wu (b)
(a) National Research Council Canada, Ottawa, Ontario
(b) Queen's University, Kingston, Ontario

Solid-state 14N NMR of amino acids and polypeptides (outline)
S.L. Veinberg (a), K.J. Harris (a), L.A. O'Dell (b) and R.W. Schurko (a)
(a) Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario
(b) National Research Council Canada, Ottawa, Ontario

14N solid-state NMR spectroscopy of pharmaceuticals and their
polymorphs
(outline)
S.L. Veinberg (a), C.R. Mireault (a), K.J. Harris (a), L.A. O'Dell (b) and R.W. Schurko (a)
(a) Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario
(b) National Research Council Canada, Ottawa, Ontario

Boron-11 Solid-State NMR of Boronic Acids (publication)
J. Weiss (a), S.-W. Oh (b), and D.L. Bryce (a)
(a) University of Ottawa, Ottawa, Ontario, Canada
(b) Mokpo National University, South Korea


13C Relaxation Rates in Solid-State Proteins at Ultrahigh Magnetic Field

Y. Wang and L. Mueller
University of California, Riverside, CA, USA

Structural Studies of the Byssus of the Blue Mussel Mytilus edulis
A. Arnold and I. Marcotte (outline)
Université du Québec à Montréal, Montréal, Québec

Nanostructured materials, electronics and energy storage

139La NMR studies in lanthanum oxides and battery materials (outline)
L. Spencer and G. Goward
McMaster University, Hamilton, Ontario

Site Populations in Mixed CO2/SO2 Clathrate Hydrates (outline)
I. Moudrakovski (a), A. Devonish (b), P. Englezos (b), and J. Ripmeester (a,b,c)
(a) Steacie Institute for Molecular Sciences, NRC Canada
(b) Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, B.C.
(c) Department of Chemistry, Carleton University, Ottawa, Ontario

High-Resolution Proton NMR for NMR Crystallography of Cellulose (outline)
C. Regnerus, K. Langendoen, D. Brouwer
Redeemer University College, Hamilton, Ontario

Local structure in MgAl Layered Double Hydroxides by High Resolution 1H, 25Mg and 27Al solid state NMR techniques. Effect of the synthesis pathways on the layer distortion
C. Forano (a,b), G.A. Facey (a), and C. Detellier (a)
(a) Center for Catalysis Research and Innovation, University of Ottawa, Canada
(b) Université Blaise Pascal, Laboratoire des Matériaux Inorganiques, France

Solid-State NMR Studies of Colossal Framework Expansion Materials

G.M. Bernard, J. Dwan, B.C. Feland, T.T. Nakashima, A. Palech, R. Teymoori, M. Wang and R.E. Wasylishen (outline)
University of Alberta, Edmonton, Alberta


Catalysts, porous materials and minerals

Natural abundance solid-state 67Zn NMR characterization of MOF-5
at ultrahigh magnetic field
(outline)
A. Sutrisno (a), S. Ding (b), W. Wang (b) and Y. Huang (a)
(a) Department of Chemistry, University of Western Ontario, London, Ontario, Canada
(b) State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China

91Zr NMR in Zirconia-Based Ceramics (publication)
O. Lapina (a) and V. Terskikh (b)
(a) Boreskov Institute of Catalysis, Russian Academy of Sciences, Russia
(b) National Research Council Canada, Ottawa, Ontario

27Al solid-state NMR studies of zirconocene/MAO polymerization
catalysts
(outline)
M.P. Hildebrand (a), A.J. Rossini (a), S.A. Johnson (a), E. Ye (b) and R.W. Schurko (a)
(a) Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario
(b) Department of Chemistry, University of Ottawa, Ottawa, Ontario

35Cl solid-state NMR of transition-metal organometallic complexes (outline)
K.E. Johnston and R.W. Schurko
Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario

Solid-state 93Nb NMR in Niobium Oxide Catalysts
O. Lapina (a) and V. Terskikh (b)
(a) Boreskov Institute of Catalysis, Russian Academy of Sciences, Russia
(b) National Research Council Canada, Ottawa, Ontario

11B MAS NMR study of phase separation in borophosphate glasses (outline)
V. Michaelis, P. Kachhadia, S. Kroeker
University of Manitoba, Winnipeg, Manitoba

11B MAS NMR of natural borate minerals (outline)
S.R. Giesbrecht (a), V.K. Michaelis (b), B. Zhou (c,d), B.L. Sherriff (e) and Scott Kroeker (a)
(a) Department of Chemistry, University of Manitoba, Winnipeg, Canada
(b) Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
(c) Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, China
(d) College of Materials Science and Engineering, Tongji University, China
(e) Department of Geological Sciences, University of Manitoba, Winnipeg, Canada

First-principles calculations and ultrahigh-field multinuclear solid-state NMR in MgSO4 polymorphs
(outline)
I. Moudrakovski (a), P. Pallister (b), and J. Ripmeester (a,b)
(a) National Research Council Canada, Ottawa, Ontario
(b) Department of Chemistry, Carleton University, Ottawa, Ontario


Advanced materials research and NMR techniques development

73Ge Solid-State NMR Investigation of Germanium Halides and Oxides Using Ultrahigh Magnetic Fields and DFT Calculations (outline)
B. Greer. V. Michaelis, and S. Kroeker
University of Manitoba, Winnipeg, Manitoba

The measurement of residual dipolar coupling between quadrupolar nuclei in double-rotation NMR
(outline)
F.A. Perras and D.L. Bryce
Department of Chemistry, University of Ottawa, Ottawa, Ontario

Characterization of 79/81Br, 35/37Cl, and 127I electric field gradient
and chemical shift tensors in a series of phosphonium halide salts
and solvates
(outline)
K.N.M. Burgess and D.L. Bryce
Department of Chemistry, University of Ottawa, Ottawa, Ontario

Solid-State 87Rb, 81Br and 127I NMR Studies of Chemical Shifts and Quadrupolar Interactions in Alkali Halide Solid Solutions
(outline)
C. Ratcliffe, J. Ripmeester, V. Terskikh
National Research Council Canada, Ottawa, Ontario

Solid-State 73Ge NMR Characterization of Organogermanium Compounds (outline)
M.A. Hanson, Y. Huang, K. Baines
University of Western Ontario, London, Ontario

Solid-State 73Ge/35Cl/79Br NMR Characterization of Low Oxidation State Germanium Halides
M.A. Hanson (a), A. Schnepf (b) and K. Baines (a)
(a) Department of Chemistry, University of Western Ontario, London, Ontario, Canada
(b) Institut für Anorganische Chemie, Universität Duisburg-Essen, Germany

14N Overtone NMR Spectroscopy (outline)
L.A. O'Dell and C.I. Ratcliffe
National Research Council Canada, Ottawa, Ontario

A solid-state 87Sr NMR investigation of some inorganic and organometallic strontium complexes (outline)
R.E. Wasylishen (a), G.M. Bernard (a), A. Palech (a), V. Terskikh (b) and E. Ye (c)
(a) Department of Chemistry, University of Alberta, Edmonton, Alberta
(b) National Research Council Canada, Ottawa, Ontario
(c) Department of Chemistry, University of Ottawa, Ottawa, Ontario

Analysis of Chloride Ion Binding Environments in Organic and Inorganic Systems Using Chlorine-35/37 Solid-State NMR Spectroscopy (outline)
B. Chapman and D.L. Bryce
Department of Chemistry, University of Ottawa, Ottawa, Ontario

Investigation of high-order quadrupole-induced effects: rhenium-185/187 solid-state NMR (outline)
C.M. Widdifield and D.L. Bryce
Department of Chemistry, University of Ottawa, Ottawa, Ontario


NMR Applications

applicationsNuclear Magnetic Resonance (NMR) spectroscopy is widely used in chemistry for structural analysis, in molecular biology and the pharmaceutical industry, in material science, as MRI in clinical diagnostic, in industry.

High-resolution large-scale version of the poster on the right (NMR applications) suitable for printing is available free of charge as a .ppt or .pdf file, please inquire.

Solid-state NMR spectroscopy has a wide and lasting impact especially on the development of novel materials: catalysts, battery materials, gas storage materials (fuel cells) and glasses. All have immediate applications in energy conservation and the reduction of greenhouse gas emissions. In the materials area, developments in nanotechnology also benefit tremendously from having access to a larger NMR periodic table than is now routinely available, and the capability to work with small samples. Another area that benefits greatly is the combinatorial approach to materials synthesis where the gain in sensitivity (small sample size) and application of ultra-fast spinning will lead to the rapid evaluation of new concepts and products. A high-field NMR facility thus allows the greatly enhanced use of a very powerful and discerning probe of solid-state structure to a wide range of applications, including:

borax nmr active sites in catalysts; framework connectivities in catalysts and glasses (structure); semiconductors, sensors, confined clusters for novel device applications; interfaces in nanostructured materials and nanocomposites; combinatorial chemistry; biomolecules, membranes and semisolids via fast spinning; polymers and polymer blends via fast spinning; dynamics in polymers and biomolecules (small, multiple-labelled samples); applications in mineral and environmental chemistry

tetracycline nmrThe new knowledge generated by solid-state NMR is finding many practical and commercial applications, for example in the petrochemical industry (catalysts, polymers), alternative energy (battery materials, fuel cells), materials fabrication (alloys), high tech materials (glasses, ceramics, nanostructured materials), electronics (novel devices), environmental applications (catalysts, sorbents, membranes, sensor materials) and pharmaceuticals.